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department of Biostatistics and Epidemiology
Helene Carabin picture

Hélène Carabin, D.V.M., Ph.D.

President’s Associates Presidential Professor

Phone: (405) 271-2229 x48083
Office: The University of Oklahoma Health Sciences Center
801 Northeast 13th Street, Room 301
Post Office Box 26901
Email: helene-carabin@ouhsc.edu

Research Interests

  • Epidemiology of infectious diseases, especially zoonotic infections
  • Assessment of the global burden of parasitic infections
  • Design and statistical analyses of clustered data
  • Application of Bayesian methods to address measurement error and clustering

Current projects as PI

  • EFECAB: Improving pig management to prevent epilepsy in Burkina Faso. This R01 project aims at using the PRECEDE PROCEED method to develop an educational package to prevent cysticercosis in humans and pigs in Burkina Faso. The effectiveness of the package will be tested in a community-based randomized controlled trial in 60 villages of the country. This is a collaboration among the Department of Biostatistics and Epidemiology at OUHSC, AFRICSanté and the University of Ouagadougou in Burkina Faso, and the Institute of Tropical Medicine in Antwerp in Belgium. Funded under the Brain Disorders in the Developing world: Research Across the Lifespan program by the National Institute of Neurological Disorders and Stroke (NINDS) and the Fogarty International Center (FIC) (R01NS064901).
  • Using Host Responses to Neurocysticercosis to Develop Novel, Brain-imaging Free Diagnostics: a US-India Partnership. This R01 project aims at developing peripheral blood makers for the diagnosis of neurocysticercosis in India. It also includes the development of local capacity to run and analyze Electrospray Ionization mass spectrometry (ESI-MS) and to develop monocyte tissue models of cysticercosis infection. This work is a collaboration among the Department of Biostatistics and Epidemiology, the Section of Infectious diseases and the department of Biochemistry and Molecular Biology at the OUHSC, the Department of Neurosciences at Christian Medical College, Vellore, India and Centre for Cellular and Molecular Platforms in Bangalore, India. Funded under the Brain Disorders in the Developing world: Research Across the Lifespan program by the National Institute of Neurological Disorders and Stroke (NINDS) and the Fogarty International Center (FIC) (R01NS098891).

Current projects as co-investigator

  • Hepatitis C in Native Oklahoma: optimizing care and setting a path towards elimination of disease and disparity. The goal of this study is to increase the capacity of the Cherokee Nation Health Services (CNHS) to screen for and provide treatment to HCV positive tribal members in the Cherokee Nation as well as understand risk factors for infection. The ultimate goal is to develop educational and clinical programs to eliminate HCV from the CNHS. I serve as the director of the epidemiology, outcomes and statistics team. This is a collaboration among the Department of Biostatistics and Epidemiology and the Section of Infectious diseases at the OUHSC, CNHS and the Center for Infectious Disease Modeling and Analysis at Yale University. Funded by the Gilead Foundation (PI: Douglas Drevets).
  • Oklahoma Shared Clinical and Translational Resources (OSTCR). The overall OSCTR mission is to serve as a catalyst for clinical research which improves health for underserved and underrepresented populations living in rural areas, to improve patient outcomes of these individuals, and to provide these resources to launch new independent IDeA investigator careers. The OSCTR will provide coordination and assistance to investigators in every aspect of clinical and translational research. I serve as the Director of the Novel Methodologies Unit of the Biostatistics, Epidemiology and Research Design Key Component Activity. Funded by the NIH/NIGMS (U54 GM104938, PI: Judith James).
  • Microbial Ecologies of Indigenous communities. This study aims at comparing the gut microbiome from extant traditional peoples to those from urban-industrialized populations to assess if a more “sanitized” lifestyle may have adversely changed our relationship with microbiomes. My role is to develop the design for data collection in Burkina Faso. Funded by the National Institute of General Medical Sciences R01GM089886. (PI: Cecil Lewis)
  • Epidemiologic and spatial methods to improve estimates of neurological disorders from population based studies. This doctoral award aims at applying epidemiologic and spatial analytic methods to identify and address selection and misclassification error biases for population estimates on two neurological disorders: epilepsy and severe chronic headaches among individuals in sub-Saharan Africa (SSA). I serve as the mentor for Ms Sahlu who is completing a PhD in epidemiology at Brown University.  Funded by the National Institute of Neurological Diseases and Stroke (F31NS093983). (PI: Ida Sahlu).

Education and Training

  • Post-Doctoral Fellow. Department of Infectious Disease Epidemiology. Imperial College, UK
  • Post-Doctoral Fellow. Wellcome Trust Centre for the Epidemiolgy of Infectious Diseases. Oxford University, UK
  • Ph.D. Department of Epidemiology and Biostatistics, McGill University, Canada
  • M.Sc. Faculté de Médecine Vétérinaire, University of Montreal, Canada
  • D.V.M. Faculté de Médecine Vétérinaire, University of Montreal, Canada

Appointments And Positions:

  • Adjunct Professor of Epidemiology, Department of Epidemiology, Brown University, 2014-present
  • Special Appointment member of Graduate Faculty at Texas A&M University in the department of Veterinary Integrative Biosciences at the College of Veterinary Medicine, Texas A&M University, 2012-present
  • Professor of Epidemiology, 2011-present.
  • Associate Professor of Epidemiology, 2006-2011.
  • Honorary Lecturer. Department of Infectious Disease and Epidemiology. Imperial College, UK, 2006-2009
  • Assistant Professor of Epidemiology, 2002-2006.

Link to most Current Publications

Selected Publications (out of 98 peer reviewed articles)

  • Mera J, Vellozzi C, Hairiri S, Carabin H, Drevets DA, Miller A, Reilley B, Essex W, Lyons L, Leston J, Ward JW. Identification and Clinical management of persons with chronic hepatitis C virus infection – Cherokee Nationm 2012-2015. MMWR Morb Mortal Wkly Rep 2016; 65: 461-6.
  • Carabin H, Millogo A, Cissé A, Gabriel S, Sahlu I, Dorny P, Bauer C, Ouédraogo J-B, Tarnagda Z, Cowan LD, Ganaba R. Prevalence of and factors associated with human cysticercosis in 60 villages of three provinces of Burkina Faso. PLoS Neglected Tropical Diseases 2015; 9(11): e0004248
  • John CC, Carabin H, Montano SM, Bangira P, Zunt JR, Peterson PK. Global research priorities for infections that affect the nervous system. Nature 2015; 527: S178-86.
  • Carabin H, McGarvey ST, Sahlu I, Tarafder MR, Joseph L, Andrade BD, Balolong E, Olveda R.Schistosoma japonicum in the Samar Province of the Philippines: infection in dogs and rats as a risk factor for the 12-month risk of infection in humans. Epidemiology and Infection 2015; 143: 1767-76.
  • Carabin H, Ndimubanzi PC, Budke C, Nguyen H, Cowan LD, Qian Y-J, Stoner JA, Rainwater L, Dickey M. Clinical manifestations associated with neurocysticercosis: A systematic review. PLoS Neglected Tropical Diseases 2011; 5(5): e1152
  • Carabin H, Gyorkos TW, Soto JC, Joseph L, Payment P, Collet J-P. Effectiveness of a training programme in reducing infections in toddlers attending daycare centres. Epidemiology 1999;10:219-227 (see editorial in Epidemiology 1999;10:209-10). This paper received the 2000 Rothman Epidemiology Prize.